Tuesday, June 11, 2013

JCI early table of contents for June 10, 2013

JCI early table of contents for June 10, 2013 [ Back to EurekAlert! ] Public release date: 10-Jun-2013
[ | E-mail | Share Share ]

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation

DNA altering enzyme is essential for blood cell development

The expression of specific genes is partially dictated by the way the DNA is packed into chromatin, a tightly packed combination of DNA and proteins known as histones. HDAC3 is a chromatin-modifying enzyme that regulates gene expression, chromatin structure, and genome instability and it has previously been shown to associate with the oncoproteins that drive leukemia and lymphoma. In this issue of the Journal of Clinical Investigation, Scott Hiebert and colleagues at Vanderbilt University examined the role of HDAC3 in the development of blood cells (hematopoiesis) by disrupting the expression of Hdac3. Loss of Hdac3 nearly eliminated all blood immune cells and caused mild anemia. Hiebert and colleagues observed that, in the absence of Hdac3, stem and progenitor cells, which give rise to blood cells, failed to grow normally. These studies identify a role for HDAC3 in stem cell functions and possibly bone marrow failure syndromes, in which the bone marrow fails to produce blood cells.

TITLE: HDAC3 is essential for DNA replication in hematopoietic progenitor cells

AUTHOR CONTACT: Scott Hiebert
Vanderbilt University School of Medicine, Nashville, TN, USA
Phone: 615.936.3582; Fax: 615-936.1750; E-mail: scott.hiebert@vanderbilt.edu

View this article at: http://www.jci.org/articles/view/60806?key=51732e44292f61add1c3


Understanding the molecular mechanisms underlying Alzheimer's disease

The accumulation of amyloid-? (A?) in the brains of Alzheimer's disease (AD) patients is known to be associated with memory loss and neuronal degeneration, but the mechanism of A? pathogenesis is not fully understood. In this issue of the Journal of Clinical Investigation, researchers led by Yong-Keun Jung at Seoul National University demonstrate that A? binds to a cellular protein known as FC?RIIb. Greater levels of FC?RIIb were detected in the brains of AD patients. Binding of A? to FC?RIIb activated cell stress and death pathways. In a mouse model of AD, depletion of FC?RIIb ameliorated memory impairment. This study demonstrates that FC?RIIb plays a critical role in AD pathogenesis.

TITLE: Fc?RIIb mediates amyloid-? neurotoxicity and memory impairment in Alzheimer's disease

AUTHOR CONTACT: Yong-Keun Jung
Seoul National University, Seoul, KOR
Phone: +82-2-880-4401; E-mail: ykjung@snu.ac.kr

View this article at: http://www.jci.org/articles/view/66827?key=09875f41f10ff79d5f1e


ALSO IN THIS ISSUE

TITLE: Transcription factor ATF3 links host adaptive response to breast cancer metastasis

AUTHOR CONTACT: Tsonwin Hai
Ohio State University, Columbus, OH, USA
Phone: 614-292-2910; Fax: 614-292-5379; E-mail: tsonwin.hai@osumc.edu

View this article at: http://www.jci.org/articles/view/64410?key=6b62d754865e0751ec4b

TITLE: Reciprocal regulation by TLR4 and TGF- in tumor-initiating stem-like cells

AUTHOR CONTACT: Keigo Machida
Keck School of Medicine - University of Southern California, Los Angeles, CA, USA
Phone: 323-443-2692; E-mail: kmachida@usc.edu

View this article at: http://www.jci.org/articles/view/65859?key=bc2ba9aa926a1c23e6f9

TITLE: Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia

AUTHOR CONTACT: Charles Mullighan
St. Jude Children's Research Hospital, Memphis, TN, USA
Phone: 901-595-3387; E-mail: Charles.Mullighan@STJUDE.ORG

View this article at: http://www.jci.org/articles/view/66203?key=2c6ee5b120aa14e3bc26

TITLE: DISC1 and SLC12A2 interaction affects human hippocampal function and connectivity

AUTHOR CONTACT: Joseph Callicott
NIMH, DIRP, NIH, Bethesda, MD, USA
Phone: 301-633-1436; Fax: 301-480-7795; E-mail: callicottj@mail.nih.gov

View this article at: http://www.jci.org/articles/view/67510?key=a8e4fb04dcd9321ca0af

TITLE: Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells

AUTHOR CONTACT: Dario C. Altieri
The Wistar Institute, Philadelphia, PA, USA
Phone: 215-495-6970; E-mail: daltieri@wistar.org

View this article at: http://www.jci.org/articles/view/67841?key=227b86a3c20385625a79

TITLE: Type 2 alveolar cells are stem cells in adult lung

AUTHOR CONTACT: Brigid Hogan
Duke medical center, Durham, NC, USA
Phone: 919 684 8085; E-mail: brigid.hogan@dm.duke.edu

View this article at: http://www.jci.org/articles/view/68782?key=a7b4317174a574a8de03

TITLE: Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis

AUTHOR CONTACT: Shyam Biswal
Johns Hopkins University, Baltimore, MD, USA
Phone: 410-955-4728; E-mail: sbiswal@jhsph.edu

View this article at: http://www.jci.org/articles/view/66353?key=92077a338c57eb874662

###


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


JCI early table of contents for June 10, 2013 [ Back to EurekAlert! ] Public release date: 10-Jun-2013
[ | E-mail | Share Share ]

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation

DNA altering enzyme is essential for blood cell development

The expression of specific genes is partially dictated by the way the DNA is packed into chromatin, a tightly packed combination of DNA and proteins known as histones. HDAC3 is a chromatin-modifying enzyme that regulates gene expression, chromatin structure, and genome instability and it has previously been shown to associate with the oncoproteins that drive leukemia and lymphoma. In this issue of the Journal of Clinical Investigation, Scott Hiebert and colleagues at Vanderbilt University examined the role of HDAC3 in the development of blood cells (hematopoiesis) by disrupting the expression of Hdac3. Loss of Hdac3 nearly eliminated all blood immune cells and caused mild anemia. Hiebert and colleagues observed that, in the absence of Hdac3, stem and progenitor cells, which give rise to blood cells, failed to grow normally. These studies identify a role for HDAC3 in stem cell functions and possibly bone marrow failure syndromes, in which the bone marrow fails to produce blood cells.

TITLE: HDAC3 is essential for DNA replication in hematopoietic progenitor cells

AUTHOR CONTACT: Scott Hiebert
Vanderbilt University School of Medicine, Nashville, TN, USA
Phone: 615.936.3582; Fax: 615-936.1750; E-mail: scott.hiebert@vanderbilt.edu

View this article at: http://www.jci.org/articles/view/60806?key=51732e44292f61add1c3


Understanding the molecular mechanisms underlying Alzheimer's disease

The accumulation of amyloid-? (A?) in the brains of Alzheimer's disease (AD) patients is known to be associated with memory loss and neuronal degeneration, but the mechanism of A? pathogenesis is not fully understood. In this issue of the Journal of Clinical Investigation, researchers led by Yong-Keun Jung at Seoul National University demonstrate that A? binds to a cellular protein known as FC?RIIb. Greater levels of FC?RIIb were detected in the brains of AD patients. Binding of A? to FC?RIIb activated cell stress and death pathways. In a mouse model of AD, depletion of FC?RIIb ameliorated memory impairment. This study demonstrates that FC?RIIb plays a critical role in AD pathogenesis.

TITLE: Fc?RIIb mediates amyloid-? neurotoxicity and memory impairment in Alzheimer's disease

AUTHOR CONTACT: Yong-Keun Jung
Seoul National University, Seoul, KOR
Phone: +82-2-880-4401; E-mail: ykjung@snu.ac.kr

View this article at: http://www.jci.org/articles/view/66827?key=09875f41f10ff79d5f1e


ALSO IN THIS ISSUE

TITLE: Transcription factor ATF3 links host adaptive response to breast cancer metastasis

AUTHOR CONTACT: Tsonwin Hai
Ohio State University, Columbus, OH, USA
Phone: 614-292-2910; Fax: 614-292-5379; E-mail: tsonwin.hai@osumc.edu

View this article at: http://www.jci.org/articles/view/64410?key=6b62d754865e0751ec4b

TITLE: Reciprocal regulation by TLR4 and TGF- in tumor-initiating stem-like cells

AUTHOR CONTACT: Keigo Machida
Keck School of Medicine - University of Southern California, Los Angeles, CA, USA
Phone: 323-443-2692; E-mail: kmachida@usc.edu

View this article at: http://www.jci.org/articles/view/65859?key=bc2ba9aa926a1c23e6f9

TITLE: Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia

AUTHOR CONTACT: Charles Mullighan
St. Jude Children's Research Hospital, Memphis, TN, USA
Phone: 901-595-3387; E-mail: Charles.Mullighan@STJUDE.ORG

View this article at: http://www.jci.org/articles/view/66203?key=2c6ee5b120aa14e3bc26

TITLE: DISC1 and SLC12A2 interaction affects human hippocampal function and connectivity

AUTHOR CONTACT: Joseph Callicott
NIMH, DIRP, NIH, Bethesda, MD, USA
Phone: 301-633-1436; Fax: 301-480-7795; E-mail: callicottj@mail.nih.gov

View this article at: http://www.jci.org/articles/view/67510?key=a8e4fb04dcd9321ca0af

TITLE: Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells

AUTHOR CONTACT: Dario C. Altieri
The Wistar Institute, Philadelphia, PA, USA
Phone: 215-495-6970; E-mail: daltieri@wistar.org

View this article at: http://www.jci.org/articles/view/67841?key=227b86a3c20385625a79

TITLE: Type 2 alveolar cells are stem cells in adult lung

AUTHOR CONTACT: Brigid Hogan
Duke medical center, Durham, NC, USA
Phone: 919 684 8085; E-mail: brigid.hogan@dm.duke.edu

View this article at: http://www.jci.org/articles/view/68782?key=a7b4317174a574a8de03

TITLE: Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis

AUTHOR CONTACT: Shyam Biswal
Johns Hopkins University, Baltimore, MD, USA
Phone: 410-955-4728; E-mail: sbiswal@jhsph.edu

View this article at: http://www.jci.org/articles/view/66353?key=92077a338c57eb874662

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-06/joci-jet060313.php

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