Kensington Introduces Colorful New Wireless Mice

I never have gotten used to those newfangled trackpads, and I always need a mouse for my computer. ?I also require a wireless mouse, and I spend a lot of time on my computer daily, so I need a comfortable mouse, too. ?Kensington is introducing a colorful new mouse that looks like it could easily [...]

Source: http://the-gadgeteer.com/2012/09/27/kensington-introduces-colorful-new-wireless-mice/

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Joslin scientists identify molecular process in fat cells that influences stress and longevity

Public release date: 26-Sep-2012
[ | E-mail | Share ]

Contact: Jeffrey Bright
jeffrey.bright@joslin.harvard.edu
617-309-1957
Joslin Diabetes Center

Finding may lead to new treatments that protect against stress and extend lifespan

BOSTON September 26, 2012 As part of their ongoing research investigating the biology of aging, the greatest risk factor for type 2 diabetes and other serious diseases, scientists at Joslin Diabetes Center have identified a new factor microRNA processing in fat tissue which plays a major role in aging and stress resistance. This finding may lead to the development of treatments that increase stress resistance and longevity and improve metabolism. The findings appear in the September 5 online edition of Cell Metabolism.

Over the past several years, it has become clear that fat cells (adipocytes) are more than just repositories to store fat. Indeed, fat cells secrete a number of substances that actively influence metabolism and systemic inflammation. Previous studies have found that reducing fat mass by caloric restriction (CR) or surgical or genetic means can promote longevity and stress resistance in species from yeast to primates. However, little is known about how CR and fat reduction produce these beneficial effects. This study investigated one type of molecular mediator change in microRNAs (miRNAs) and the processing enzymes required to make them that is influenced by aging and reversed by caloric restriction. miRNAs are involved in the formation of mature RNA.

Based on studies conducted using human cells, mice and C. elegans (a microscopic worm used as a model organism for aging studies), the researchers demonstrated that levels of multiple miRNAs, decrease in fat tissue (adipose) with age in all three species. This is due to a decrease in the critical enzyme required from converted pre-miRNAs to mature miRNAs, Dicer. In the human study, which compared the miRNA levels in preadipocytes (fat cell precusors) of young, middle-aged and older people, people aged 70 and older had the lowest miRNA levels. "The fact that this change occurs in humans, mice and worms points to its significance as a general and important process," says lead author C. Ronald Kahn, MD, Chief Academic Officer at Joslin Diabetes Center and the Mary K. Iacocca Professor of Medicine at Harvard Medical School.

Caloric restriction, which has been shown to prolong lifespan and improve stress resistance in both mice and worms, prevents this decline of Dicer, and in the case of the mice, restore miRNAs to levels observed in young mice. Conversely, exposure of adipocytes to major stressors associated with aging and metabolic diseases, including toxic agents, Dicer levels decreased. Mice and worms engineered to have decreased Dicer expression in fat showed increased sensitivity to stress, a sign of premature aging. By contrast, worms engineered to "overexpress" Dicer in the intestine (the adipose tissue equivalent in worms) had greater stress resistance and lived longer.

Overall, these studies showed that regulation of miRNA processing in adipose-related tissues plays an important role in longevity and an organism's ability to respond to age-related and environmental stress. "This study points to a completely new mechanism by which fat might affect lifespan and is the first time that anyone has looked at fat and miRNAs as factors in longevity," according to co-author T. Keith Blackwell, MD, PhD, co-head of Joslin's Section on Islet Cell and Regenerative Biology and Professor of Pathology at Harvard Medical School.

Based on this study, Blackwell suggests that "finding ways to improve miRNA processing to keep miRNA levels up during aging might have a role in protecting against the stresses of everyday life and the development of age- and stress-related disease."

Dr. Kahn and the study investigators are currently working on ways to genetically control Dicer levels in the fat tissues of mice, to create mouse models that are more or less resistant to stress. "We would love to find drugs that would mimic this genetic manipulation to produce a beneficial effect," says Dr. Kahn. "If we can better understand the biology of aging, we might also understand how age impacts diabetes," says Kahn.

###

Study co-authors include Marcelo A. Mori, Prashant Raghavan, Jeremie Boucher, Stacey Robida-Stubbs, Yazmin Macotela, Steven J. Russell, and T. Keith Blackwell of Joslin; and James L. Kirkland and Thomas Thomou of the Mayo Clinic.

About Joslin Diabetes Center

Joslin Diabetes Center, located in Boston, Massachusetts, is the world's largest diabetes research and clinical care organization. Joslin is dedicated to ensuring that people with diabetes live long, healthy lives and offers real hope and progress toward diabetes prevention and a cure. Joslin is an independent, nonprofit institution affiliated with Harvard Medical School.

Our mission is to prevent, treat and cure diabetes. Our vision is a world free of diabetes and its complications.

For more information , visit www.joslin.org.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 26-Sep-2012
[ | E-mail | Share ]

Contact: Jeffrey Bright
jeffrey.bright@joslin.harvard.edu
617-309-1957
Joslin Diabetes Center

Finding may lead to new treatments that protect against stress and extend lifespan

BOSTON September 26, 2012 As part of their ongoing research investigating the biology of aging, the greatest risk factor for type 2 diabetes and other serious diseases, scientists at Joslin Diabetes Center have identified a new factor microRNA processing in fat tissue which plays a major role in aging and stress resistance. This finding may lead to the development of treatments that increase stress resistance and longevity and improve metabolism. The findings appear in the September 5 online edition of Cell Metabolism.

Over the past several years, it has become clear that fat cells (adipocytes) are more than just repositories to store fat. Indeed, fat cells secrete a number of substances that actively influence metabolism and systemic inflammation. Previous studies have found that reducing fat mass by caloric restriction (CR) or surgical or genetic means can promote longevity and stress resistance in species from yeast to primates. However, little is known about how CR and fat reduction produce these beneficial effects. This study investigated one type of molecular mediator change in microRNAs (miRNAs) and the processing enzymes required to make them that is influenced by aging and reversed by caloric restriction. miRNAs are involved in the formation of mature RNA.

Based on studies conducted using human cells, mice and C. elegans (a microscopic worm used as a model organism for aging studies), the researchers demonstrated that levels of multiple miRNAs, decrease in fat tissue (adipose) with age in all three species. This is due to a decrease in the critical enzyme required from converted pre-miRNAs to mature miRNAs, Dicer. In the human study, which compared the miRNA levels in preadipocytes (fat cell precusors) of young, middle-aged and older people, people aged 70 and older had the lowest miRNA levels. "The fact that this change occurs in humans, mice and worms points to its significance as a general and important process," says lead author C. Ronald Kahn, MD, Chief Academic Officer at Joslin Diabetes Center and the Mary K. Iacocca Professor of Medicine at Harvard Medical School.

Caloric restriction, which has been shown to prolong lifespan and improve stress resistance in both mice and worms, prevents this decline of Dicer, and in the case of the mice, restore miRNAs to levels observed in young mice. Conversely, exposure of adipocytes to major stressors associated with aging and metabolic diseases, including toxic agents, Dicer levels decreased. Mice and worms engineered to have decreased Dicer expression in fat showed increased sensitivity to stress, a sign of premature aging. By contrast, worms engineered to "overexpress" Dicer in the intestine (the adipose tissue equivalent in worms) had greater stress resistance and lived longer.

Overall, these studies showed that regulation of miRNA processing in adipose-related tissues plays an important role in longevity and an organism's ability to respond to age-related and environmental stress. "This study points to a completely new mechanism by which fat might affect lifespan and is the first time that anyone has looked at fat and miRNAs as factors in longevity," according to co-author T. Keith Blackwell, MD, PhD, co-head of Joslin's Section on Islet Cell and Regenerative Biology and Professor of Pathology at Harvard Medical School.

Based on this study, Blackwell suggests that "finding ways to improve miRNA processing to keep miRNA levels up during aging might have a role in protecting against the stresses of everyday life and the development of age- and stress-related disease."

Dr. Kahn and the study investigators are currently working on ways to genetically control Dicer levels in the fat tissues of mice, to create mouse models that are more or less resistant to stress. "We would love to find drugs that would mimic this genetic manipulation to produce a beneficial effect," says Dr. Kahn. "If we can better understand the biology of aging, we might also understand how age impacts diabetes," says Kahn.

###

Study co-authors include Marcelo A. Mori, Prashant Raghavan, Jeremie Boucher, Stacey Robida-Stubbs, Yazmin Macotela, Steven J. Russell, and T. Keith Blackwell of Joslin; and James L. Kirkland and Thomas Thomou of the Mayo Clinic.

About Joslin Diabetes Center

Joslin Diabetes Center, located in Boston, Massachusetts, is the world's largest diabetes research and clinical care organization. Joslin is dedicated to ensuring that people with diabetes live long, healthy lives and offers real hope and progress toward diabetes prevention and a cure. Joslin is an independent, nonprofit institution affiliated with Harvard Medical School.

Our mission is to prevent, treat and cure diabetes. Our vision is a world free of diabetes and its complications.

For more information , visit www.joslin.org.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-09/jdc-jsi092112.php

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HTC One X+ makes first unofficial appearance

A T-Mobile-branded HTC One X+ has made its first appearance appearance on Twitter in a wholly unofficial manner. Though we don't get much more than this brief glimpse, we've heard previously about a handful of specs.

• Size: 134.36 x 69.9 x 9.3mm
• Weight: 129g
• NVIDIA AP37 1.6GHZ quad core, 1.7GHZ single core
• ROM:32GB
• RAM: 1 GB
• Battery: 1800 mAh
• Android 4.1 Sense 4.5

Keep in mind that this is all well within the realm of speculation for the time being, but so far, things are looking pretty solid. The only other upcoming HTC device really on our radar at this point is the Droid Incredible X,, which may be finding its way to Verizon. 

In any case, there doesn't seem to be anything particularly exciting about the front face of this device. I'm curious to see the other side, if only to get a sense of what kind of camera is on there. Any T-Mobile customers itching for a fresh HTC phone? 

Source: @evleaks

Source: http://feedproxy.google.com/~r/androidcentral/~3/L5nn-tp8Z48/story01.htm

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Obama flubs line on jobs, says he's "channelling" Romney

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Obama ahead of Romney in Iowa polls as vote starts

DES MOINES, Iowa (AP) ? Republican Mitt Romney is struggling in swing-state Iowa at a perilous point: just as voters here start casting early ballots in the presidential race.

President Barack Obama has a clear lead in Iowa opinion polls, helped by the fact that the state's economy is far more robust than other battleground states. The president's polling edge is so wide it has prompted grumbling among Iowa Republicans who fault Romney for failing to take advantage of Obama's standing, which had been weakened in the four years since Iowa launched his bid for the White House in 2008.

"There still is time to win, but we are in the fourth quarter," said Nick Ryan, a veteran Iowa Republican strategist who was a top adviser to Pennsylvania Sen. Rick Santorum's caucus campaign.

Iowa is hardly the largest prize in the race for 270 Electoral College votes. But the six it offers could be pivotal if the race is close.

Iowans on Thursday can begin voting in person at early voting sites and returning absentee ballots they've requested by mail or in person. Iowa Republicans are mindful that the perception of Romney in deep trouble could sway voters already casting ballots ? or dissuade volunteers from encouraging backers to turn out at the polls.

The state knows Romney and Obama well; both competed here in 2008. And Romney came close to winning its caucuses in January.

"A lot of people I know are excited about Romney," said Susan Geddes, a Republican from Indianola, just south of Des Moines. "And a lot of people I talk to are like me, and just want it over with."

Since locking up the GOP nomination in the spring, Romney has visited the state six times and has poured $8 million into television advertising here. GOP-leaning groups have tried to help, spending $20 million in TV ads criticizing Obama. But Romney hasn't been to the state since Sept. 7, when he made a trip to the Republican-heavy northwest. And he has paid scant attention to the blue-collar voters along Iowa's eastern edge, where unemployment is running higher than in the state overall and where he needs a big turnout to overtake Obama.

The Republican's team insists that he hasn't given up on the state and that he and his running mate, Paul Ryan, plan to spend more time in Iowa in the final weeks of the campaign.

"You're going to see the governor and Paul Ryan talking a lot directly to voters, having more opportunities to do that," campaign spokeswoman Sarah Pompei said.

Aides argue that Romney has built a more sophisticated voter-contact system than Republican John McCain did in 2008, when Obama carried Iowa by 9 percentage points. And although Romney has only 14 staffed state campaign offices, compared with Obama's 67, Republicans say they have made more than 1 million contacts with voters by telephone and in person.

If the polls are right, the GOP ticket has a lot of ground to make up.

A Wall Street Journal/NBC News/Marist Poll taken last week found Romney trailing Obama by 8 percentage points, a finding that mirrored recent internal polls from Democrats and Republicans alike. The poll also found that only 40 percent had positive feelings about Romney, down from 43 percent in May. Conversely, Obama saw his favorability rating improve to 53 percent from 48 percent over that same period.

Those figures illustrate why Obama's campaign is increasingly confident about its Iowa prospects even as aides say they expect the race to tighten somewhat as undecided voters focus on the election.

Democrats say Obama has benefited from his Iowa strategy of blanketing the state with eight presidential visits ahead of early voting. Obama hoped that his frequent visits, as well as constant appearances by Vice President Joe Biden and first lady Michelle Obama, would help him build a lead over Romney ahead of Election Day, when Republicans traditionally have had an edge.

Obama focused his attention on more populous and politically diverse eastern Iowa. The small and medium-sized cities, many with struggling manufacturing sectors, were friendly territory for Romney in the Iowa caucuses but now show him trailing Obama in internal polling. Obama's three-day, statewide trip in August touched down in less-traveled cities in north- and south-central Iowa. He also made a well-publicized visit to the Iowa State Fair in Des Moines.

The president also has run more than $20 million in ads, including many that characterize Romney and his positions as those of a wealthy, detached former business executive. Obama allies also have spent roughly $3 million in advertising.

Obama aides say Romney's criticism of Obama's handling of the economy has been less effective here than it has been in states such as harder-hit Florida and Nevada. In August, Iowa unemployment was 5.5 percent, up from July but far below the national average of 8.1 percent.

But Obama aides also say Romney hasn't made as much of an effort to build a personal connection with voters in a state where face-to-face campaigning is key, and they say his comment about 47 percent of Americans who don't pay federal income tax has been problematic.

"He doesn't think poor people are his problem," Oskaloosa Democrat Pam Douglas said. "They are his problem if he wants to be president."

___

Associated Press writer Julie Pace in Chicago contributed to this report.

Source: http://news.yahoo.com/obama-ahead-romney-iowa-polls-vote-starts-070455613--election.html

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How Auto Repair Shops Maintain Your Car Suspension in ...

Last updated 1 day 7 hours ago

To understand how Auto Repair Shops maintain your car suspension system?in Woodstock GA, Cherokee County, and the Towne Lake Area,?take some time to learn about the system?s most essential components. ?Driving your car would be one bumpy ride if you didn?t have a working suspension system. Your car wouldn?t last long either without suspension.?

Coil Springs

Coil springs are the most common type of spring system found in front and rear suspension systems. These heavy-duty springs coil themselves around the axis of the chassis. When your wheels and tires hit an uneven part of the road the coil springs absorb the movement of the wheels.

Dampers

Once the suspension coil springs accept the extra energy from the wheel, they need a little help dissipating that energy. Springs don?t dispel energy fast enough on their own; they tend to oscillate for quite a while after being depressed. Dampers accept the excess energy from the spring and dampen it quickly to get ready for the next shock. Here?s how dampers do it: the damper, or shock absorber, takes the kinetic energy from the shock and turns it into heat. Inside the damper is a hydraulic fluid which quickly dissipates heat and absorbs the shock.

Struts

Struts also work as shock absorbers. Mounted inside the coil spring, struts provide more weight and structural support than dampers. While dampers slow down the speed of the shock, struts control how the structure of the car itself handles the movement.

Anti-Sway Bars

Of course, not all pot holes and pavement obstacles are created equal, and potholes or road obstacles usually affect one side of the car more than the other. That?s where anti-sway bars come in. Anti-sway bars shift weight to the non-affected wheels of the vehicle when the opposite wheels take a dip or a hike. This keeps the other side of the vehicle connected to the road at all times in order to maintain stability and control.

If your car?s suspension isn?t what it used to be, do yourself a favor and get it fixed at Aero Automotive. We specialize in domestic and imported auto repairs and light truck repairs in Woodstock, GA. We?re also Woodstock?s choice for Volvo and Triumph repairs. Give us a call at (678) 809-7478 for more information.?

Source: http://www.carrepairswoodstock.com/538506/2012/09/18/how-auto-repair-shops-maintain-your-car-suspension-in-woodstock-ga-.html

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How To Send Email Customers Want To Read | Empower Network ...

If you want to build a good reputation as an online business, regular contact with your customer base is key. Email marketing can be a fantastic way to accomplish this. Below are some great tips to help increase the success of your email marketing campaign.

Testimonials are an effective email marketing tool. Let your reader know how this email will benefit them right this second. End your email with a call to action, enticing them to click through your link and make a purchase.

Always proofread your emails. You need to make sure all emails and newsletters are correct. Before sending out your email, test the layout in a few different email clients to be sure it can be read the way you would like it to be read. Ensure that every link is working, as well.

TIP! Your marketing emails should contain rich content to complement the request for business. Offer special articles to your subscribers that may not be on your site.

Select one day every week to send out your newsletter, based on what the email says and what your subscribers? schedules look like. Unsurprisingly, business newsletters are most successful when they are sent on business days. If you send out a newsletter that targets families, or one that is devoted to leisure activities, you should mail it on the weekend.

You must build an organic email opt-in list if you wish for your marketing campaign to succeed. That means that you should not buy an email list that probably won?t include people who are interested in the products you sell. Instead, grow your subscriber base over time with people who are interested in what you are selling.

Mix up the format of your emails every once in awhile to keep things interesting. If you typically send out email marketing messages composed in HTML, then occasionally send one or two of them using a plain text layout. When well-written, this could give your consumers an emotional avenue when it comes to your services and products.

TIP! When creating an email list, create it organically. You should never buy or rent an email address list.

Use your emails to give your customers incentives. When they have a reason to do business, they often will. Offering coupons, discounts, sales or free shipping only available to email subscribers is a great way to keep them on your opt-in list.

You can increase the loyalty of your customers by personalizing their emails. Take advantage of the opportunity to tell them about new discounts or special offers. Send information about products based on what they previously purchased. Customers who already trust you and have a relationship with you are easier to convert for sales than new customers.

You may want to try sending emails with no images. Images may look interesting and fun, but they often slow load times for emails. Also, many email clients won?t display images without the client?s interaction. Many people will be viewing the email on slower connections, or connections with metered bandwidth, so keep that in mind. Focus on the content more than any images you might include. You will create a loyal customer base this way.

TIP! To encourage the growth of your marketing campaign, combine your marketing emails with social media marketing using Facebook, Twitter, and other outlets. Your customers may share newsletters and other marketing materials online, which will help you get more new customers.

Give different options to your customers for an effective campaign. Let the subscriber dictate how often they would like to get messages from your business, how much personal information they relinquish to you, and how many emails they would like from you in a given period of time. The more choices customers have, the more they will see the business relationship as equal and mutually beneficial.

Emails are a wonderful way to follow up with your customers. When you?re sending the follow up email, consider adding in a coupon for a future purchase. Add a link in your email and ask them to follow it for more information. Give your customer a compelling reason to click by offering great savings on their purchase.

Only send customers emails that contain information they can use. Do not abuse their confidence by giving them sales petitions that are blatant in nature. Attempt to make sure that each and every email you send out contains unique discounts, offers, coupons, or just useful and enlightening knowledge.

TIP! Be sure that your strategy is persistently pursued. It is essential that you have the correct clients in mind, or your work is worthless.

If you desire to succeed in your business, you must have a great marketing plan. Email marketing strategies should always be a part of these plans. Use the tips above to make the most of your email marketing, so that you can be the success you hope to be in your business

Source: http://www.empowernetwork.com/fmoro/internet-marketing/how-to-send-email-customers-want-to-read/

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Witnesses say woman claimed to be at "Fatal Vision" murders

WILMINGTON, North Carolina (Reuters) - Several witnesses testified on Tuesday that a now-dead woman with a history of drug abuse told them she was at the home of an Army doctor on the night his family was killed 42 years ago, evidence he hopes will bolster his claim that he is innocent of the notorious murders that inspired a best-selling book.

Former Green Beret Jeffrey MacDonald, 68, is serving three life sentences for the deaths of his pregnant wife and two young daughters in their Fort Bragg, North Carolina, apartment in February 1970.

MacDonald has always insisted the murders were committed by drug-crazed intruders, including a blonde woman who he said carried a candle and chanted "acid is groovy, kill the pigs" while three men attacked him and killed his wife, Colette, and daughters Kristen and Kimberley, ages 2 and 5.

MacDonald, whose case inspired the bestseller "Fatal Vision," this week is asking a federal judge in Wilmington to give him a new trial based on evidence collected since his 1979 conviction.

An appeals court ruled last year that the evidence, including DNA results from unidentified hair found at the crime scene, must be weighed in light of all the other facts previously gathered rather than considered piecemeal.

A key focus of the defense case is the now-deceased Helena Stoeckley, who is thought by MacDonald's supporters to be the woman he said witnessed the murders.

At MacDonald's trial, Stoeckley testified that she could not remember what she was doing that night and had no recollection of being in the house. But witnesses who testified on Tuesday said she told them a different story.

Wendy Rouder, a law clerk for the defense during the 1979 trial, said a day or two after Stoeckley testified, she told Rouder that she had in fact been in the MacDonald home during the crime.

Stoeckley said she remembered holding a candle, "only it was not dripping wax, it was dripping blood," Rouder said.

Rouder said she asked Stoeckley why she did not say that on the witness stand and Stoeckley said, "I can't with those damn prosecutors sitting there."

MacDonald's defense contends that the lead prosecutor in the case intimidated Stoeckley into changing her testimony to avoid facing a murder charge herself. The basis for their claim is a sworn statement by a former federal marshal who said he heard the prosecutor threaten Stoeckley.

The former marshal also is dead. Prosecutors have sought to poke holes in his claim, questioning his character and why he waited until 2005 to come forward.

Prosecutors say no evidence supported MacDonald's scenario about intruders killing his family and contend he staged the crime scene to cover his tracks.

Helena Stoeckley's younger brother and Sara McMann, who let Stoeckley live with her shortly before her 1983 death, also testified on Tuesday that she had admitted to being inside the MacDonald home.

McMann said Stoeckley told her she went to the house with some men on the night of the murders and that they only planned to rough up Jeffrey MacDonald. The men had promised Stoeckley that if she went with them "she would become a wizard in the occult group," McMann said.

"She was haunted with nightmares about that," said McMann, who through tears added, "I know as well as I'm sitting here today that Jeffrey MacDonald is innocent."

The hearing, which is expected to last up to 10 days, resumes on Wednesday.

(Reporting by Judy Royal; Writing by Colleen Jenkins; Editing by Tim Gaynor)

Source: http://news.yahoo.com/witnesses-woman-claimed-fatal-vision-murders-014748979.html

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Even in the out-there world of quantum computing, there?s a use for Scotch tape, according to researchers who used the adhesive to give a se... Read more

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John Roach

University entrance exams have been the stuff of cram sessions and nightmares for people around the world for centuries. Now, it?s a robot?s... Read more

Source: http://www.nbcnews.com/technology/futureoftech#/technology/futureoftech/lifewatch-phone-pocket-sized-doctors-office-1B5946723

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